Cholinesterase Inhibition by Parathion in vivo
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منابع مشابه
Cholinesterase inhibition in vitro by OO-diethyl O-p-nitrophenyl thiophosphate (parathion, E 605).
00 Diethyl 0 -p -nitrophenyl thiophosphate (I), generally known as parathion or E 605, is an insecticide which is of value against a variety of crop pests. Its mammalian toxicity is usually ascribed to its power of inhibiting cholinesterase, and this is also possibly its mechanism of insecticidal action. The in vitro inhibition of the enzyme was first studied by DuBois, Doull, Salerno & Coon (1...
متن کاملInhibition of cholinesterase by dialkylcarbamates.
The pI50 index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N',N'-dialkylcarbamates were determined. Index pL50 (pI50 = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient...
متن کاملStudies on cholinesterase: 5. The selective inhibition of pseudo-cholinesterase in vivo.
Bruce, H. M. & Callow, R. K. (1934). Biochem. J. 28, 517. Grsholm, A. (1935). Beretn. f. Form0o8lab., 168. Copenhagen. Harrison, D. C. & Mellanby, E. (1939). Biochem. J. 38, 1660. Hoff-Jorgensen, E. (1944). Det. kgl. danske Viden8kabernee Selskabs mat.-fy8. Medd. 21, 7 (in English). Larson, C. E. & Greenberg, D. M. (1938). J. biol. Chem. 123, 199. McCance, R. A. & Widdowson, E. M. (1935). Bioch...
متن کاملThe Mechanism of in Vitro and in Vivo Inhibition of Cholinesterase Activity by Diisopropyl Fluorophosphate
cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...
متن کاملMechanism of in vitro and in vivo inhibition of cholinesterase activity by diisopropyl fluorophosphate.
cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...
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ژورنال
عنوان ژورنال: Nature
سال: 1951
ISSN: 0028-0836,1476-4687
DOI: 10.1038/168998a0